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Goffman identified a "frame" – or framework – as "schemata of interpretation" to locate, perceive, identify and label situations, experience, meaning, etc. [ 7].
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We confirmed the stop codon between all2620 and all2619 and could not identify a frame shift in the sequence of the region 500 bp upstream or downstream of the stop codon.
We ran UCSC BLAT search (Kent, 2002) and NCBI BLAST (Altschul et al., 1997) and used ENSEMBL (Flicek et al., 2011) to identify a frame enabled correct translation of exons from both proteins participating in chimeras.
We identified a sampling frame that balanced breadth of sampling for general inference with sensible investment of resources on replication projects.
Yang et al. [[ 19]] identified a TaGW2 frame-shift mutation in a large-kernel variety, and associated this mutant allele with increased grain width and TGW in a large F2 3 population.
A screen of non- BRCA1 or BRCA2 mutant familiar breast tumors identified a in-frame deletion of residue 81 glutamic acid of Rap80 that displays reduced ubiquitin binding and compromised ability to recruit A complex and BRCA1 to DSBs [ 73].
From the corresponding Xenopus genomic sequence, we identified an in-frame ATG start codon starting 33 bp upstream and positioned 51 bp downstream of an in-frame stop codon; we annotated this ATG as the start codon for Xenopus heparanase 2, and this prediction concurs with that of Gnomon, the NCBI gene prediction tool (XM_002937183.2).
For PEG10 we identified an in-frame CUG codon 102 nucleotides (equivalent to 34 amino acids) upstream of the AUG codon.
Finally, the authors identified an in-frame genomic translocation event between MAGI3 and AKT3 [ 10].
We also identified an in-frame deletion/insertion (c.513_530del), which is predicted to result in a p.Asp171_Glu177delinsGlu in a single family with MED.
Genetic analyses based on across-breed comparisons efficiently shortlisted the number of candidate causative variants and ultimately identified an in-frame exon skipping mutation in UBE3B.
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