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Our systems approach identified a disruption of the cell cycle not readily apparent from a ranked list of genes.
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Despite this limitation, both confocal microscopy and Western blot identified a disruption in the normal process of filamin A cleavage in U. parvum infected cells.
Because a concussion is an injury that interferes with the normal function of the brain-it is diagnosed through identifying a disruption in brain function 8.
By using a very site-specific drug, performing for the first time simultaneous measurements of CMRglc, rCBF, resting state BOLD low frequency oscillations, and analyzing both dexmedetomidine-induced loss of consciousness and recovery, we have been able to identify a minimal disruption of neural networks that is shared between altered consciousness states.
In addition to the mutants that were depleted at 43°C, we identified a number of processes for which disruption resulted in a significant growth advantage compared to growth at 30°C.
The speakers identified a wide range of possible threats, from the disruption of almost half of New York City's water supply to the loss of trees and streams in a 20-acre arboretum in northern Westchester.
Collectively, all our data identified the disruption of the Dnmt1/PCNA/UHRF1 interactions as a molecular event associated with the degree of global DNA hypomethylation in glial/glioma cells.
DOI: http://dx.doi.org/10.7554/eLife.03656.007 If the relatively compact conformation of the RRE results from the tertiary interactions identified earlier, disruption of those interactions is predicted to result in a more extended conformation.
Bury 28 identified the disruption of taken-for-granted behaviours such as general activities of daily living and the disruption of self-concept; all of which are supported by our data.
Autoimmune bullous diseases (ABDs) represent a group of rare, acquired disorders characterized by overlapping features, resistance to treatment, and potential lethality. 1 The most important pathophysiologic mechanisms in the skin of these patients have been identified as disruption of the host immune system, which leads to clinical blister formation.
In an in vitro splicing assay, the mutation resulted in the skipping of exon 3. We have identified a novel MRAP mutation where disruption of the intron 3 splice-site results in a prematurely terminated translation product.
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