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On further analysis we identified a cut off score of ≥200 for COX-2 expression, which could serve as a marker of aggressive disease and poor survival.
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It is not clear what led the ADA panel to change its 2010 recommendations because the HAPO study fails to identify a cut off level for plasma glucose predictive of an increased risk for the mother and the baby, whereas, as recommended by the UK National Screening Committee (3), defining a clear threshold should be a prerequisite for a screening test.
This observation is similar to the one reported by Higgins and coworkers [8], who identified a cut-off value at 100 beats per minute as independent predictor of hospital mortality in a selected population of CABG patients.
We deliberately identified a cut-off with 100% specificity such that we can be confident not to miss unrecognized adrenal insufficiency.
We identified a cut-off for PCT level useful to rule out the presence of Candida spp. with a high negative predictive value.
The ROC analysis identified a cut-off serum concentration with a high sensitivity and a good specificity to identify breast cancer patients.
We identified a cut-off value of 8 cm and a mitotic rate of 5 per 50 high power fields (HPF) to be most predictive for cancer-specific survival.
Univariate analyses identified a cut-off of inspired oxygen concentration (FiO2) of 70%% and age in three stages (<60, 60 75 and >75 years) for testing in the multivariate models.
For Ki-67 expression in cStageIII, the ROC curve analysis identified a cut-off for the CR group of 33.7% that provided 70% sensitivity and 70% specificity, with a PPV of 43.8% and a NPV of 87.5%.
To investigate this possibility, we performed 1000 simulations in which we randomly identified a cut-off for each district and then looked at the difference in the gradients of the slopes before and after the random cut-off points.
The usefulness of preoperative BNP measurements as a predictor of perioperative cardiac events was also reported by Cuthbertson and co-workers, who identified a cut-off of preoperative BNP > 40 pg/mL to be associated with a 5-fold increase in the risk of developing either postoperative cTnI elevation > 0.32 ng/mL or new ECG abnormalities [ 27].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com