Retrospective case series have identified coronary artery bypass grafting (CABG) as a tool in reducing the incidence of recurrent arrest and prolonging survival after STEMI OOHCA [ 23, 24].
Several members of the Y family of DNA polymerases have been identified that could bypass the γ-OH-PdG adduct.
The possibility remains that conditions will be identified that permit bypass of Stn1 and or Ten1 but not of Cdc13.
We use all relevant records from the provincial population-based registry of CAD patients identified as needing bypass surgery.
Four distinct patient groups were identified: coronary artery bypass graft (CABG; n = 5), mitral/aortic valve replacement (n = 2), other surgery (n = 9) and warfarin reversal (n = 8).
DOI: http://dx.doi.org/10.7554/eLife.00459.019 10.7554/eLiFigure59.020 Figure 4 figure supplement 3. Results of a screen to identify multicopy bypass suppressors of the Δart1 ts phenotype.
Translation of this strategy to humans would allow clinicians to treat elderly patients after mitochondrial or significant muscle dysfunction is identified, thus bypassing the need for costly long-term preventative treatments.
We then used genome-wide screening to identify other bypass suppressors of mps3 ∆ as well as other deletions in membrane (mps2 ∆ and nbp1 ∆) and half-bridge (cdc31 ∆, kar1 ∆, and sfi1 ∆) components of the SPB to better understand interactions between the SPB and NPC and to discover new factors that regulate SPB duplication and NE insertion.
Indeed, CBX7 was first identified in a screen for bypass of replicative senescence (Gil et al., 2004).
Based on this rationale, we performed a screen to identify bypass suppressors of the Δart1 mutant temperature sensitive phenotype in order to uncover other components of the ART-Rsp5 network or new pathways for PM protein quality control.
Focusing on utilization of PHC facilities among care-takers seeking care for their underfive children in rural Tanzania, this study aimed to 1) establish the frequency of bypassing such facilities 2) identify factors influencing bypass and, 3) explore experiences, at such facilities, of caretakers seeking care for their under-five children.
