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The identification of widespread chromatin changes during SCLC progression reveals an unexpected global reprogramming during metastatic progression.
Disease was confirmed by identification of widespread PrPd accumulation in the CNS by immunohistochemistry (Fig 1a) and detection of proteinase K resistant PrPSc by Western blotting.
Indeed, this study provides insights into the dynamic changes in DNA methylation in response to Pi starvation, with the identification of widespread changes in DNA methylation near PSI genes, in a species-dependent manner, likely correlated with the TE content of the genome.
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A recent screening allowed the identification of four widespread mutations, I161V, G265A, F330Y and G368A.
Molecular epidemiological tools and genotyping of M. tuberculosis strains have identified different families and genotypes contributing to a better knowledge of the transmission dynamics of TB and identification of certain genotypes more widespread than others [2].
The widespread identification of individuals most at risk could enable early detection and management strategy.
Gene expression profiling and GCH studies have suggested specific favourable and unfavourable NB signatures (Takita et al, 2004; Ohira et al, 2005; Vandesompele et al, 2005), but presently a widespread identification of patients at risk of relapse by these techniques cannot be envisaged.
Later in the day, when I dropped in on my friend Frank Green, he asked me whether I had obtained my new Home Relief identification card, now being issued because of widespread chicanery.
The need for a national health identification number has been the object of widespread mobilization of French epidemiologists in the last 10 years, notably when DMPs were created [ 10].
The analysis of the 10 ITS systems consisted of an identification of potential barriers regarding the widespread use of the ITS systems in the EU-28, as well as recommendations to overcome these barriers.
Large-scale chemical mutagenesis screens in zebrafish led to the identification of many mutants that displayed widespread, apparently non-tissue-specific abnormalities [26], [27].
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