Advances in esophageal manometry have facilitated identification of variants of achalasia, suggesting they are more common than previously thought.
Improvements in high-throughput screening methods have facilitated the rapid identification of variants with improved biosynthetic capabilities.
The identification of variants that are unable to bind membrane receptor preparations (MRPs) has previously been shown to select attenuated yellow fever and Japanese encephalitis viruses.
The various SP enantiomers of O-alkyl-methylphosphonyl esters of CHMC provide suitable ligands for screening rePON1 libraries, and can expedite identification of variants with enhanced catalytic proficiency towards the toxic nerve agents.
The geographic heterogeneity in genetic variation identified in this study has important implications for the identification of variants associated with disease or other clinically relevant outcomes.
As mentioned, in correspondence of false positive calls local coverage was low even when the average coverage depth was high, indicating a direct influence of the mapping procedure on automated identification of variants.
We show that one round of shuffling using the 27 trypsinogen entry plasmids can easily produce the 19,683 different possible combinations in one single restriction-ligation and that expression screening of a subset of the library allows identification of variants that can lead to higher expression levels of trypsin activity.
Although we have incorporated all available published pharmacogenomic studies of statin efficacy into our combined analysis, this study is probably still underpowered and identification of variants with statistically meaningful association to statin efficacy will require analyses in expanded populations once GWA data from additional trials becomes available.
A crucial part of next-generation genome sequencing data analysis is the identification of variants.
Identification of variants in the alignment files was performed using the Genome Analysis Toolkit [ 30].
In an experimental population, markers allow for the easy identification of variants.
