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The main novelty of the paper consists in the optimization of the considered models by the appropriate identification of the minimum and more representative training dataset.
The main finding of this work is identification of the minimum required number of PARs and their best distribution among the associated compartments.
A novel method is presented for the systematic identification of the minimum requirements regarding mathematical pre-treatment, a priori information, or experimental design, in order to allow optimising rate constants and pure component spectra associated with a kinetic model via multivariate kinetic hard-modelling of spectroscopic data.
Another technique relied on the identification of the minimum of the average magnitude difference function (AMDF) between two signals, which was recently modified by joint consideration of the AMDF and the average magnitude sum function (AMSF) to improve the performance in reverberant environment [13].
Usually, analyses of this type have concentrated on the identification of the minimum set of sites required to represent all species at least once [2].
Identification of the minimum frequency for CHX application required to reduce the number of PRPs on the teeth may promote the routine use of this intervention for MV-ICU patients.
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Where the use of minimum cheese content was adequate to characterize the products covered, and if so, identification of the relevant minimum contents.
Then, the three main steps of the method are described: the skeleton extraction and pruning algorithm, the definition and computation of a travel cost between all pairs of skeleton vertices, and the identification of the directed minimum spanning tree in the resulting directed graph.
Sampling of guest conformations and identification of the global minimum conformation could therefore be done at a relatively fine granularity.
The computation of recurrence (9) reduces to the identification of the column minima in an on-line upper triangular matrix B. One can easily show that when w satisfies the concave Monge condition, B is totally monotone.
Our results may be helpful in the structural identification and understanding of the minimum structural requirements for these molecules and might provide a guide in the design of new aggregation modulating ligands.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com