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Additionally, the identification of the interface between telomerase and the telomere will allow more targeted approaches to alter telomerase recruitment as a potential therapeutic approach for human diseases.
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Additional topics include prediction of oligomerization state of membrane proteins, identification of the interfaces for protein protein interactions, and design of membrane proteins.
For example, identification of the interfaces of the aberrant oligomers helps explain why Cu2Zn2SOD1S S is so resistant to oligomerization, and potentially, why many of the ALS mutants localize to the dimer or the metal-binding region.
This deformation of the lower segment makes identification of the cervicovaginal interface and vaginal fornices difficult.
The crystal structure determination of Hyal/Fab 21E11 complex (2.6 Å) enabled the identification of the Hyal IgG interface which provides indirect information on the Hyal IgE interaction (B-cell epitope).
The observation that these IKK2 homodimers can exhibit varying degrees of opening has allowed identification of the dimerization interface within the portion of the SDD distal to the KD ULD.
Spectroscopic identification of this interface, however, remains a great challenge.
The result from a t-test shows that the confidence of the instrumented drilling system in identification of the geotechnical interfaces is up to 99%.
The address resolution mechanism impacts on the design of the MAC local address since it should allow for identification of the client interfaces on both ends of the PON.
The method performs extremely well in identification of the non-interface residues.
Moreover, identification of the most crucial interfaces could lead to the development of new antibiotics that block pathogenic infection by disrupting the array and eliminating chemotaxis, rather than by destroying all pathogenic and nonpathogenic bacteria.
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