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The identification of signals from cells adjacent to pancreatic tumours that boost liver colonization might suggest ways to block this deadly form of cancer invasion.
In this context, this review deals with strengths, limitations and future trends in the identification of signals highlighted by API-MS-based metabolomics.
The cellular and molecular mechanisms underlying this fascinating phenomenon are beginning to emerge, including substantial progress in the identification of signals that control regenerative growth of the zebrafish caudal fin.
We report on an experimental model for the regeneration of a CSD in the axolotl (the Excisional Regeneration Model) that allows for the identification of signals to induce fibroblast dedifferentiation and skeletal regeneration.
With clinical evidence demonstrating that sustained hypertrophy is a key risk factor in heart failure development, much effort is centered on the identification of signals and pathways leading to pathological hypertrophy for future rational drug design in heart failure therapy.
The identification of signals that regulate autophagy and genes that execute autophagy has assisted in the development of reagents to manipulate the autophagy pathway.
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Martz CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A, et al. Systematic identification of signaling pathways with potential to confer anticancer drug resistance.
Weihofen, A., Binns, K., Lemberg, M.K., Ashman, K. & Martoglio, B. Identification of signal peptide peptidase, a presenilin-type aspartic protease.
Nevertheless, significant progress has been made in the identification of signaling pathways and master regulators for drought tolerance.
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Justyna Jupowicz-Kozak
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