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Finally, we apply these methods to experimental case-control data and demonstrate successful identification of published genetic susceptibility loci for a rare monogenic disease (sudden infant death with dysgenesis of the testes syndrome), a rare complex disease (progressive supranuclear palsy), and a common complex disease (Alzheimer disease) across multiple SNP genotyping platforms.
Careful screening of search results and communication with investigators ensured identification of published and unpublished reports.
Reference lists were hand-search for further identification of published work, presentations at scientific meetings and personal communications.
Moreover, we cannot completely rule out selection bias in the identification of published reports from the search strategy.
SSL supervised the identification of published literature and SMF read and classified articles according to reported secondary uses.
This sampling frame may have resulted in the identification of published systematic reviews that have a better-than-average quality of reporting.
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Identification and categorization of published measures of specialty care referral can be considered the first step toward assessment of the referral system.
The process of constructing a systematic review, a document that compiles the published evidence pertaining to a specified medical topic, is intensely time-consuming, often taking a team of researchers over a year, with the identification of relevant published research comprising a substantial portion of the effort.
Applying these methods to experimental case control data, they also demonstrated the successful identification of previously published susceptible loci for a rare monogenic disease, a rare complex disease and a common complex disease.
The realist review reported here will inform the second work package of this EU project through the identification of quantitative published peer-reviewed literature with regard to diabetes self-management arrangements currently in place (within the health care systems of the different partner countries) and how these are integrated into the broader welfare systems.
For cases where the automated pipeline fails, we developed a plug-in to DOMEO, a semantic literature annotation tool described below that facilitates the identification of resources inside of published papers by curators and subsequent export of these data for use in the NIF system.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com