Exact(1)
As highlighted below, there is a good agreement between the genes that change expression with age and the genes required for the effect of DR. This encourages identification of lifespan regulating genes based on changes in their age-associated expression.
Similar(59)
Interestingly, there are several wild-derived N. furzeri strains that differ strikingly in their captive lifespan by 2- to 3-fold (Terzibasi et al. 2008), potentially allowing the identification of novel genes regulating lifespan in vertebrates by linkage mapping and comparative genomics.
Drosophila has proven itself an important model for the identification of genes that regulate lifespan [ 50].
The strong developmental phenotypes of mutations inactivating DAF-2 pathway signaling facilitate genetic identification of mutations that affect lifespan.
The identification of genes that modulate healthy lifespan is a major goal of research on aging.
Invertebrate model species like yeast, worm and fly have been successfully used to study the genetic background of lifespan determination and ageing, leading to the identification of a number of relevant genes and pathways [ 1].
This standing genetic variance has enabled mapping of lifespan QTL [3], [39] and led to precise identification of additional candidate genes for aging [33], [40].
Extension of lifespan promoted by certain genetic and/or pharmacological perturbations will more likely lead to identification of bona fide regulatory factors of aging.
This study predicted the amount and pattern of sedimentation for use in estimation of the useful lifespan of reservoirs and identification of optimal locations for outlets and intakes at the initial stages of dam design.
The C. elegans Lifespan Machine and its application to the temperature scaling of lifespan.
Multiple determinants of lifespan memory differences.
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