Therefore, identification of the key steps limiting the catabolism of glycerol will have a major impact on improving bioconversion efficiency of glycerol.
By flux analysis, the pathway mode leading to maximal production yield was simplified with identification of key reaction steps.
Cedars-Sinai's approach to the automation of gated perfusion single photon emission computed tomography (SPECT) imaging is based on the identification of key procedural steps (processing, quantitation, reporting), each of which is then implemented, in completely automated fashion, by use of mathematic algorithms and logical rules combined into expert systems.
This gives insights on the relative contributions of the different metabolic branches and as to how metabolite levels and metabolic fluxes are modulated and lead to identification of key regulatory steps, resulting in a global view of regulations and metabolic schemes in Plasmodium.
We therefore undertook a comprehensive redesign of the instructions, including identification of each key step, development of short instructions for each step, and creation of graphics to clarify and reinforce the text.
Mapping the location of these CNA hotspots facilitates location of genes of potential importance to tumor development as well as identification of alterations forming key steps in tumor development.
The analysis steps included identification of key miRNAs deregulated in HCC from different reports in the literature [16,31 37,47], followed by identification of their target genes using an integrated in silico approach.
In summary, the careful selection of key components, identification of key characteristics and understanding of critical manufacturing steps are determinants of whether the nanoparticles will have the desired pharmacodynamics, PK, and safety profiles to achieve the intended therapeutic effects.
Identification of key altered genomic loci constitutes a first step to find the genes that drive the alteration in a malignant state.
Identification of key signaling molecules and pathways relevant to ERα- breast cancer is therefore an important step toward the goal of improving breast cancer therapy [ 3- 5].
