The identification of interfaces between partner molecules provides targets for pharmacological intervention; the protein-protein interaction surface between Bcl-xL and cytochrome c here identified may offer one of these targets.
Identification of interfaces between the sectorial and national strategies of cassava-producing countries in order for the Strategy to receive adequate attention from policy-makers.
Interestingly in-depth assessment of our approach to identification of interaction interface residues solely from Cα positions points to structural contexts where the proposed approach identifies interface residues more effectively than the traditional approaches which use positions of other atoms such as those in the sidechains.
Spectroscopic identification of this interface, however, remains a great challenge.
Identification of binding interface region is especially useful for cellular pathways analysis and drug design.
An approach is proposed based on situated action techniques for the early identification of user interface issues and their translation into design factors that lead to design improvements.
Open image in new window Figure 3 Identification of binding interface between EV71 and SCARB2.
Additionally, the identification of the interface between telomerase and the telomere will allow more targeted approaches to alter telomerase recruitment as a potential therapeutic approach for human diseases.
Additional topics include prediction of oligomerization state of membrane proteins, identification of the interfaces for protein protein interactions, and design of membrane proteins.
The identification of protein interfaces has been based on several criteria such as solvent accessibility (ASA), distances cut-off, conservation residues [12], [13], [14].
