Sentence examples for identification of inducers from inspiring English sources
We have suggested a possible application of K562 cell clones stably transfected with constructs expressing the BCL11A-XL gene in the identification of inducers able to stimulate HbF production via downregulation of the γ-globin gene repressor BCL11A-XL.
The evidence for PCD in unicellular eukaryotes (Kingdom: Protista or Protozoa) has largely come in the form of laboratory identification of the inducers of PCD and demonstrations of the apoptosis phenotype.
Herein we review three recent approaches that have been developed for inducing these so-called silent biosynthetic gene clusters: insertion of constitutively active promoters using CRISPR-Cas9, high-throughput elicitor screening for identification of small molecule inducers, and reporter-guided mutant selection for creation of overproducing strains.
Although, the pluripotent EC cells are much less used nowadays, they remain a useful model for the identification of small molecule inducers for myogenic differentiation [ 46].
Identification of effective paraptotic inducers and the elucidation of critical signals involved in this alternative cell death mode may facilitate the design of novel therapeutics against malignant cancer cells with defects in their apoptotic machineries.
The search for MMP-inducing factors in tumour cells leads to the identification of extracellular MMP inducer (EMMPRIN), whose name reflects its EMMPRIN activity.
Ishimatsu-Tsuji, Y., Soma, T. & Kishimoto, J. Identification of novel hair-growth inducers by means of connectivity mapping.
This study provides a new strategy to discover herbal compounds for tumor treatment and disease alleviation that may assist with the identification of tumor cell autophagy inducers in the future.
Our identification of Klu as a tumor inducer in Drosophila NBs may help to further clarify the role of these genes in tumor formation.
Another key discovery in the 1960s was the identification of poly(I C) as an inducer of interferon in rabbits.
The identification of SM and Traf2 knockdown as inducers of RIP1 kinase-mediated TNF α production suggests that RIP1 kinase activation might be regulated directly by ubiquitination by cIAP1/2 and/or Traf2.
