Identification of high frequency clusters is important for developing specific treatment guidelines and better patient management.
Identification of high frequency of mutations in potential epigenetic regulators (DNMT3A, TET2, IDH1, IDH2, ASXL1, and UTX) is particularly interesting.
Although out of the scope of the present study, the identification of higher frequency of HBV/F-HDV/3 genotypes among symptomatic patients with liver disease seeking medical care in an outpatient clinic, confirms the poorer clinical outcomes determined by these genotypes.
The identification of high-frequency histone mutations in pediatric high-grade gliomas has given us an inroad to better understand and to treat these deadly tumors.
Thus, the large-scale identification of high-frequency codons in Chinese bayberry, especially the high-frequency codon pairs (Additional file 4), could be used as a reference in design of exogenous transgenes.
The methods employed include: 1) Tests designed to identify deviations of the Site Frequency Spectrum (SFS) from neutral expectations (Tajima's D, Fay and Wu's H and Fu and Li's D* and Fu's F*), 2) Tests focused on the identification of high-frequency haplotypes with extended Linkage Disequilibrium (LD) (iHS and Rsb) and 3) Tests based on genetic differentiation between populations (LSBL).
The overall accuracy of the gene predictions herein were also supported by the identification of higher frequencies in nucleotide variants in the intronic regions than in the exons for both heterokaryotic and homokaryotic SNPs (Additional file 3).
Prediction accuracy was also supported by the identification of higher frequencies in nucleotide variants in the intergenic space (0.89 ± 0.01 SNPs/kb) and intronic regions (0.57 ± 0.07 SNPs/kb) than in the exons (0.35 ± 0.04 SNPs/kb; Additional file 5: Table S3).
First, 'picture identification' tests candidates' listening comprehension of high frequency words (4500 English vocabulary; see College Entrance Examination Center, CEEC, 2016a) and sentence structures.
The test for positive selection requires identification of a core haplotype with a combination of high frequency and high EHH, as compared to other core haplotypes at the locus (Sabeti et al. 2002).
The information of high frequency dielectric properties of different types of cell lines enables the detection and signature identification of cells in a microfluidic device at microwave frequencies.
