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The web-based tool allows straightforward exploration of combination data, and easier identification of correlations between compound properties and interactions.
This type of study is useful, because plant lines produced by intensive breeding selection are available that have different degrees of tolerance, which helps in the identification of correlations between responsive genes and observed stress-tolerance phenotypes.
Population structure can confound the identification of correlations in biological data.
The advantage of that study was the larger pool of data (139 compounds), which theoretically should help identification of correlations.
Even though, identification of correlations being stable across all studied conditions helps to detect close metabolic relationships, such as e.g. pyruvate/malate, pyruvate/α-ketoglutarate or pyruvate/valine.
Correction for multiplicity of testing is planned by identification of correlations between the variables, i.e. those of autonomic tone.
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The optimization was constrained to the Northern Hemisphere and to regions with at least 15° of latitudinal extent and 62.5° of longitudinal extent to avoid identification of correlation pockets over implausibly small regions.
Testing of construct validity was undertaken through the identification of correlation coefficients between the behaviour variables recorded and women's and observers' views of the support received or observed.
The usage of such matrices goes with global bioinformatics strategies that help to elucidate regulation mechanisms: comparative genomics, identification of over-represented motifs, identification of correlation between binding sites,... Similar matrix-based models also serve to represent splice sites in messenger RNAs [ 3] or signatures in amino acid sequences [ 4].
The computation of a p-value allows the detection of such false identifications of correlations.
Spearman's nonparametric correlation coefficient and linear regression were used for the identification of significant correlations between continuous variables.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com