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This culminated in the identification of compound 31 as an optimized renin inhibitor.
This resulted in the identification of compound 34 with an IC50 of 2.6 μM.
This study allowed the identification of compound 5l, as the first dual hAK/hGSK-3β inhibitor reported to date.
Our efforts resulted in the identification of compound 4a which significantly reduced food intake with minimal systemic exposure in rodents.
These efforts led to the identification of compound 41, which demonstrates in vivo activity in our study.
These compounds were evaluated for PAK4 inhibition, leading to the identification of compound 9d (PAK4 IC50 = 0.033 μM).
These assays allowed the identification of compound LASSBio-1135 (3as an anti-inflammatoryory and analgesic symbiotic prototype.
Optimization leads to the identification of compound 3c, a potent and orally available agent with improved physicochemical and pharmacokinetic properties.
The results of the biological evaluation led to the identification of compound 12 as dual HDAC6/HSP90 inhibitor.
In this paper, we explore an efficient identification of compound emotions in sentences using hidden Markov models (HMMs).
Subsequent SAR optimization resulted in identification of compound 46 with high human A2BAdoR affinity (Ki = 13 nM), selectivity against other AdoR subtypes and with good pharmacokinetic properties.
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CEO of Professional Science Editing for Scientists @ prosciediting.com