Sentence examples for identification of apc from inspiring English sources
Identification of APC subsets in fetal and adult tissues.
Jump now to hereditary colon cancer and the identification of APC as the tumor suppressor responsible for Familial Adenomatous Polyposis [ 38].
The identification of APC and the localization in skin and lymphoid organs is consistent with previous studies assessing marsupial immune systems (Coutinho et al., 1995; Cisternas and Armati, 2000).
Identification of APC mutations and loss of heterozygosity (LOH) in approximately half of sporadic colorectal adenomas and majority of adenocarcinomas indicates that APC inactivation is an early event in tumor progression (i.e. initiation).
12, 13 Since the identification of the APC gene, more than 1,100 unique likely pathogenic germline mutations have been reported (http://www.lovd.nl/apc).nl/apc
274 MS/MS spectra obtained over the course of 2-hour gradient separation were analyzed with the MASCOT search engine, resulting in identification of all 13 APC subunits (see supplementary Report S3).
The identification of the full APC model was based on the same assumption as those used in previous French analyses.
Therefore identification of other pathways downstream of Apc loss, in particular those highly active in LGR5 ISCs may provide candidates to target APC-deficient cells.
Future identification of the ubiquitination site(s) in APC will enable mutational analysis and more conclusive determination of the importance of K63-lined ubiquitination of APC in Wnt signaling and other APC-regulated cellular processes.
Identification of additional downstream factors that meditate the effects of APC mutations could lead to effective therapeutic approaches to treat colorectal cancers and FAP.
Tanaka, M. et al. Identification of candidate cooperative genes of the Apc mutation in transformation of the colon epithelial cell by retroviral insertional mutagenesis.
