"Knowledge of what makes cells die and of what can block the cell-death process in the nematode may help lead to the identification of agents that can regulate the cell deaths involved in a variety of human disorders, such as cancer and neurodegenerative diseases," Dr. Horvitz said.
The inhibition of tumor cell proliferation by monoclonal antibody recognizing the C1q site on gC1qR, as well as the identification of agents such as anthracyclin that enhance cC1qR/CR expression on tumor cells, are indeed steps in the right direction.
The identification of agents with the potential to trigger this transition is of great interest.
In comparison to the blood-stage parasite SMI screening assays [19] the screening and identification of agents that inhibit Plasmodium development in the liver is considerably more complex.
The development of an efficient therapeutic approach would therefore require the identification of distinctive molecular pathways active in CSCs and the identification of agents that can either block CSC proliferation or induce CSC differentiation, thus enhancing sensitivity to chemotherapeutic drugs.
To accelerate identification of agents targeting CRSCs, the Connectivity Map (CMap) approach was used.
Montpelier Centre nomenclature for the identification of agents of human leishmaniases was used to classify the organisms.
Contemporaneous with these foregoing developments are identification of agents with novel targets (e.g., intranasal ketamine, agents that target cellular bioenergetics/inflammation).
For these reasons, the development of methods and the identification of agents to increase UCB HSC homing, engraftment or HSC number is of significant therapeutic value.
The design of existing epidemiologic studies on cleaning has not allowed identification of agents responsible for asthma and other reported respiratory symptoms.
