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The first step is the identification of a template protein of known structure.
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Our experimental and theoretical results allow the identification of a topographical template which can serve as a guide for the design of new compounds with antifungal properties for potential therapeutic applications against these pathogenic fungi.
The process of virtual library enumeration starts out by the identification of a lipid template for the specified lipid abbreviation.
Identification of distinct template and product exit tunnels allows proposal of a detailed model for template-directed replication with minimal disruption to the circularised RNP.
These observations indicated that the presence of the initially biased sequence may interfere with the identification of individual template clusters.
Initial PCR amplification and resequencing using the parental genotypes of the F1 NA6 × AU6) mapping population allowed identification of a further 35 secondary R gene template sequences (Additional File 2).
To get to the bottom of this problem, an unambiguous template for the identification of a specific combination of CD antigens on the lymphoblasts was essential, which is easily evident and stably expressed at the onset of ALL and whose altered expression could be an index for consistent monitoring of the disease status, during and post-chemotherapy.
However, for target sequences with low sequence similarity, the reliable identification of structural templates and accurate sequence-structure alignment requires a much more complex process called threading or fold recognition that integrates many other types of information with sequence profile information.
To build a structure model for a target protein sequence, the TBM process consists of four major steps: identification of structural templates, alignment of target sequence to structural templates (or sequence-structure alignment), model building, and model quality evaluation.
Secondly, the identification of sub-templates has to be specific in COSMIC versus the dynamic inclusion criteria of archetype slots.
The following items are checked in the validation process of each conversion: 1. Identification of COSMIC templates and archetypes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com