Since the identification of a cyclin partner would allow us to assess whether Lsk1p activity was regulated by modifications in cyclin stability and/or localization we decided to determine whether such a physiologically relevant cyclin sub-unit existed in S. pombe.
For the identification of a compensatory partner for the COIII-Phe251Leu mutation we followed a similar approach.
We then focused on the question of how the cells can differentially regulate the two xMELK subpopulations, with a particular emphasis on identification of an xMELK partner involved in spatial and temporal regulations of specific localizations of the two subpopulations of xMELK.
Following identification of a local BH partner, an interagency workgroup was established, comprised of leadership and line level stakeholders from both JJ and BH agencies.
The identification of a novel PrPC partner in lipid rafts of neuronal cells favors the idea of a role of PrP in multiple functions.
Since this compound is moving toward clinical development, the identification of a suitable drug partner will be crucial, and it will be important to monitor the possible emergence of mutations in the pfcarl locus and particularly at position 1076.
In line with the original identification of Bora as a partner of Aurora A (Hutterer et al. 2006), co-immunoprecipitation between the N terminus of hBora and endogenous Aurora A could readily be confirmed (ESM Fig. S 3A).
48 The TET family of genes (TET1, TET2, and TET3) have been implicated as tumor suppressors in hematological malignancies, initially with the identification of TET1 as a partner of MLL in rare chromosomal translocations 49 and, later, by the demonstration of acquired mutations targeting TET2 in various myeloid disorders, including AML.
While our libraries are large and diverse, it is probable that identification of a surrogate peptide with partner information is a rare event.
In this work we present the identification of a novel MLL fusion partner in a pediatric patient with de novo biphenotypic acute leukemia.
