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The identification of a link does not imply cause and effect, of course.
The generation of many mouse mutants carrying defects in repair pathways yielded valuable models for assessing the clinical relevance of DNA repair including carcinogenesis and the identification of a link between DNA damage and premature aging.
An investigation of the relationship between repair of DNA ICL damage, cell-cycle response, and cell death enabled the identification of a link between HR repair and ICL-induced G2 arrest in mammalian cells.
The identification of a link between TTP expression and the E6-induced cell transformation provides new insights into the molecular mechanism by which HPV 16 or 18 viruses cause cervical cancer.
The identification of a link between INH resistance and mutations in Mtb type II NADH-menaquinone oxidoreductase (Ndh-2) is consistent with the present understanding that increased NADH reduces the frequency of INH-NAD (or ETA-NAD) adduct formation, which subsequently decreases its binding to InhA, the known target of INH (Refs 13, 11).
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A related problem is identification of a causal link between state alcohol taxes and drinking outcomes, including excessive drinking and alcohol-related harms.
The identification and characterization for the first time of the PIK3CA 5' upstream regulatory region confirmed that PIK3CA is an important mediator of tumor cell response to stress in vivo and enabled the identification of a molecular link between inflammation and tumor growth mediated by NF-κB and p110α.
However, the coexistence of different biological mechanisms does not preclude the identification of a statistical link with one specific measurement.
A particularly interesting finding of above gene expression profiling and pathway analysis is the identification of a novel link between NF-κB2 and IL-10.
In addition, these analyses allow the identification of a metabolic link between the LCA and the first steps in the structure of biological networks [ 14– 16].
DNA sequencing of a substantial proportion of the GP60 gene, including the microsatellite region, provides higher resolution data than investigating microsatellite length polymorphisms, which may mask differences in sequence (8 ); here, DNA sequencing facilitated identification of a significant link between subtype and foreign travel outside Europe.
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