Sentence examples for identification of a lead from inspiring English sources

This exercise resulted in the identification of a lead compound with improved drug-like characteristics and activity.

CADD can be used to aid in the identification of a lead compound for epilepsy by rational drug design.

The systematic variation of the pharmacophoric groups led to the identification of a lead compound that demonstrated micromolar affinity for the mGluR5.

A medicinal chemistry effort centered on the identification of a lead series with the potential of delivering such compounds is described in this Letter.

The SAR studies resulted in the identification of a lead compound that is more potent and more soluble than L-870810.

These results led to the consideration of topical delivery of these molecules, and to the identification of a lead molecule 7 which shows promising PK and PD in a murine model of pulmonary hypertension after intra-tracheal dosing.

We report the identification of a lead-like small compound, 160, which blocks NS2-mediated proteolysis at the NS2-NS3 junctinn in vitro.

Screening of the in-house sample collection for compounds with HCV NS5B RNA dependent RNA polymerase inhibition led to the identification of a new lead.

The goal of any hit-to-lead effort is the identification of an optimal lead series and its liabilities for transition to lead optimization efforts.

This study resulted in the identification of a promising lead inhibitor of FAK (42), which also showed activity in a wound healing and cell invasion assay.

The identification of a proper lead compound for fructose 1,6-bisphosphatase (FBPase) is a critical step in the process of developing novel therapeutics against type-2 diabetes.