Moreover, the identification of a threshold of LOH could help in predicting patients with poor outcome who may be candidates for local or systemic adjuvant therapies.
23 The identification of a threshold response in human salivary glucose concentration is intriguing.
The concept of a safe dose is based upon the identification of a threshold for an adverse effect.
In practice, identification of a threshold may be entirely dependent on personal judgment, particularly for conditions with a relatively small evidence base regarding the natural history of disease and effects of treatment.
The models have produced similar predictions regarding the ecology and management of bTB in badger populations, including the identification of a threshold badger group size of around 6 8 individuals for disease persistence.
Furthermore, the ability to probe a given target with multiple siRNA duplexes should decrease the impact of off-target effects on hit identification, if one sets a threshold that a minimum of two non-overlapping siRNA duplexes should yield an overlapping phenotype [11].
Next, the expert panel performed a threshold identification exercise designed to assess the members' willingness to enrol 47 paper cases, based on having sufficient confidence that the individual has gout, into a Phase 3 randomised clinical trial of a new urate-lowering agent with unclear efficacy and safety.
The original 30 paper patient cases (except for 3 with demonstrated MSU crystals), in addition to 20 subjects from the SUGAR study analysed in Phase 1 who had unique scores close to the cut-off score derived as described above, were used for a threshold identification exercise.
Assuming that the resistivity ratio of bedrock and fracture fluid is 3000 1, for low-angle fractures, the smallest detectable aperture can be less than 10 μm when we set 10%% (the dotted line in Fig. 6a) as an identification threshold in terms of the ratio of the resistivity of the fracture and the bedrock (the formula in Fig. 6a).
The performance of the e-model by different point thresholds for the identification of diabetes corroborated using a threshold of 1 point to optimize sensitivity and specificity.
