Exact(4)
Identical alterations were identified in 43% of fluids from matched cancer tissues harboring changes.
In seven out of seventeen cases where there was abnormal DNA methylation in the ART sample (41%), the identical alterations were present in the parental sperm.
Interestingly, pre-malignant lesions (such as adenomas) share identical alterations in miRNA expression with carcinoma, suggesting that the acquisition of cancer-specific profiles represents an early event in the malignant process [ 2].
Zhuang et al. evaluated genetic clonality by using a polymorphic marker flanking the APC gene locus in 12 patients of BA as well as their IM and dysplasia, and found that identical alterations were observed in BA, dysplasia and some IM tissue [ 34].
Similar(56)
Clonal (identical alteration in 2 or more cells) and non-clonal alterations associated with smoking history participate in the tumor initiation process.
Analysis of corresponding gastric and lymph node metastatic lesions, MT10 and MG10 cells, revealed the presence of identical gene alterations.
Analysis of the M10 cells-derived metastatic MT10 and MG10 cells revealed the presence of identical gene alterations (data not shown).
They detected identical microsatellite alterations in corresponding serum, sputum and surgical margins.
Pretest and posttest content was identical, with alterations in the ordering of questions to reduce re-test bias.
In the end we might obtain models that carry almost identical genetic alterations of oncogenic pathways as we can distinguish them today.
Genomic DNA sequencing was also performed on heterozygous sequence variants to confirm that identical sequence alterations were present in genomic DNA.
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