We can perhaps agree that antibodies should ideally be validated in a manner that closely mimics how it is used in the actual application.
Ideally, to validate and calibrate the DIA tools one should seek the most direct reference values (RV) that answer the same question as the algorithm is intended to do [ 7].
Intravenous insulin is ideally administered via validated written or computerized protocols that allow for predefined adjustments to the insulin infusion rate according to glycemic fluctuations and insulin dose.
It is vital that the accuracy and reliability of companion diagnostic tests be maximised and that the cut-offs are validated, ideally in clinical trials or at least in prespecified analyses of retrospective samples from prospectively conducted clinical trials.
For making judgments about generalisability it is important to consider the characteristics of the sample from which the model was derived, the clear presentation of the results and finally the model should, ideally, be evaluated (validated) in a different sample from the original.
Ideally, guidelines should be validated, adapted to local conditions, and improved on the basis of the results of locally or nationally available surveillance or sentinel hospital studies.
DDS: Devaluation Discrimination Scale; GASS: Generalised Anxiety Stigma Scale; DSS: Depression Stigma Scale Ideally, a new measure should be validated against an existing validated measure of the construct.
PRO measures should, ideally, be re-validated in each study using whatever data are available for the validation: for instance, the relation between the PRO and other related outcomes measured.
Therefore, massively parallel sequencing is ideally suited to validate other mutation detection methodologies.
Ideally, we would validate our single cell pathway model by tracking Erk activation in cells making different types of contacts under controlled conditions.
