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The IDEAL trial, Spiegel says, reflects the kind of things that Schering will be doing under Hassan to better address the needs of its customers.
Both John McHutchison John McHutchison, director of hepatology research at the Duke Clinical Research Institute, who is heading up the IDEAL trial, and Michael Fried Michael Fried, director of hepatology at the University of North Carolina in Chapel Hill, point out two such inferences.
Similar interventions were done in the A to Z trial and the IDEAL trial.
Presumably their ideal trial would involve unmotivated participants and untrained, inexperienced investigators.
Thus, of course, the ideal trial is one in which the power is high.
4. The Incremental Decrease in End Points Through Aggressive Lipid Lowering (IDEAL) trial.
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Elements of ideal trials designs for successful antiepileptogenic intervention are suggested.
Response rates with gefitinib were varied, but most reports described disease control rates of >40%, comparable with data from the Phase II IDEAL trials.
Recent data on the relationship between EGFR expression levels and the response to gefitinib are now available from the Phase II IDEAL trials and the EAP.
Correlation between dose and skin rash was also evident in the Phase II IDEAL trials, where gefitinib 500 mg day−1 was associated with a higher incidence of rash but similar objective response rates and survival as the 250 mg day−1 dose.
Response rates ranged between 20% for patients pretreated with one or two chemotherapy lines (IDEAL-1 trial) and 10% for patients pretreated with two or more chemotherapy lines (IDEAL-2 trial).
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