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Owing to the utilization of CL detection, this protocol showed ideal sensitivity for quantitation.
Urine sCD163 concentrations also had an ideal sensitivity and specificity for the diagnosis of sepsis.
Complementary DNA methylation biomarkers that reach an ideal sensitivity and specificity rather than a single one for detecting CINs have not been successful so far.
In this large cross-sectional study performed in an Asian population of relatively pure ethnic background an HbA1c of 5.45% was the closest value to the point with ideal sensitivity and specificity for the diagnosis of MS and IFG.
Overall, there is credible evidence of less than ideal sensitivity with the current testing technology (affected cases with normal concentration when tested at birth) and specificity (relatively high rate of false-positive results, including cases with relatively high levels that are followed up by perfectly normal plasma acylcarnitine and urine organic acid profiles).
There is evidence of less than ideal sensitivity with the current testing technology (affected cases with normal concentration when tested at birth) and poor specificity (very high rate of false positive results, mostly premature babies and newborns with liver disease of variable etiology).
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In these settings, there is a high prevalence (pre-test probability) of HIV and TB; even in an exam in which findings are only suggestive (non-ideal sensitivity and specificity) of TB, these findings may be enough to predict the presence of the disease (post-test probability).
Near ideal pH sensitivity has been achieved.
For high accuracy it is ideal that sensitivity and specificity have somewhat reasonably high percentages, i.e., > 80%.
The best threshold was the one that minimized the distance to the ideal point (sensitivity = specificity = 1) on the ROC curve.
Continuous variables were transformed into dichotomous variables using the receiver operating curve (ROC); specifically, we determined the optimal threshold that minimized the distance to the ideal point (sensitivity = specificity = 1) on the ROC curve.
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CEO of Professional Science Editing for Scientists @ prosciediting.com