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The ideal proof-of-principle study design provides a strong efficacy signal over the shortest duration, while exposing the fewest patients possible.
Although the double resistance reporter assay is an ideal proof-of-principle model, it is not very versatile in gene engineering.
As the amyloid cascade is the leading hypothesis, this cohort would be ideal for proof-of-principle studies in amyloid-based drug therapy.
My main reason for posing it is that it has a solution from 'The Book', the book of ideal proofs invented by Paul Erdos.
This group would be the ideal cohort for proof-of-principle studies for amyloid targeted therapies, but this is unfortunately precluded by the rarity of mutation carriers.
The rib-wall face was otherwise clear of any clutter, which provided ideal conditions for initial proof-of-concept testing.
Due to the extensive use of this collection, these STRs are well-defined and scrupulously characterized, proving ideal substrates for this proof-of-concept study.
Although discrimination of colitic from non-colitic mice by non-invasive factors is ideal, as a proof of principle for discriminatory modeling and to gain biological insight into the mucosal disease process tissue PLS-DA models were generated using the colon levels of the factors.
This setup has very simple self-consistency relations, which makes it an ideal test-bed for a proof-of-principle demonstration of a hybrid quantum-classical scheme.
This novel isolation of equine cord blood MSCs and their preliminary in vitro differentiation positions the horse as the ideal pre-clinical animal model for proof-of-principle studies of cord blood derived MSCs.
If these ideals continue to inspire filmmakers around the world, it's due largely to the films on which Lubtchansky worked, which validate and honor those ideals and provide enduring proof of their artistic vitality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com