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According to the WAO Task Force, the ideal efficacy study of specific allergen immunotherapy should be performed in monosensitized patients or in patients concomitantly sensitized to noncross-reacting allergens.
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The non-ideal efficacy of SFs is thought as the biggest barrier which hinders the improvement of the molecular docking method.
However, the non-ideal efficacy of scoring functions is thought as the biggest barrier which hinders the improvement of the molecular docking method.
However, several barriers need to be overcome in order to achieve ideal therapeutic efficacy.
This is a small animal (weighing approximately 400 g), which is ideal for efficacy testing in an early development phase of a new drug, when only limited amounts of the compound are available.
Randomised controlled trials will be required to show that these devices can deliver this ambition in ideal circumstances (efficacy) and in the usual clinical setting of any ICU across the globe (effectiveness).
A placebo-controlled randomized controlled trial (RCT) design is ideal for efficacy evaluation because it minimizes bias through multiple mechanisms, such as standardization of the intervention and double blinding.
A sham or placebo intervention group is the ideal method for efficacy studies with an optimal, strictly restricted design to minimise all influencing factors to prove the efficacy of a specific component of the intervention.
Increased fetal hemoglobin (HbF) expression is beneficial for β-hemoglobinopathy patients; however, current inducing agents do not possess the ideal combination of efficacy, safety and ease of use.
One is the conflict between long-circulation and cellular uptake while the other one is the achievement of ideal anti-cancer efficacy.
However, it has been suggested that instead of a single siRNA, using a combination of 2 3 siRNAs targeting multiple genomic regions may be ideal to enhance efficacy and reduce viral escape as well as off-target effects [16].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com