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The principal idea proposed here is to utilize an optimal controller (a modified linear quadratic regulator) to practically evaluate the best achievable control performance for each candidate design during process design.
Under the idea proposed here, an aspiring entrepreneur will be matched with a promising technology or business idea.
A thorough justification is as follows: The idea proposed here is the manifestation of the spectrum of autonomy which is responsibility-sensitive in a sense that the definition of autonomy by Holec 1981 is once more spotlighted.
It should be pointed out that the influence of the wheelset's yaw angle on the normal contact solution is essential for wheel-roller contact and can be included based on the similar idea proposed here, but it will not be discussed further in the current paper for simplicity.
The idea proposed here circumvents the inherent difficulties associated with the current understanding of tumorigenesis, and is also consistent with many experimental and epidemiological observations.
Although risk assessment applications can involve a range of phases or steps (two to five are common in regulatory programs), the key idea proposed here is the iterative development of information appropriate to answering the problem at hand.
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Author response: A quantitative analysis based on the ideas proposed here will indeed be worthwhile, and I believe that it will greatly facilitate the beginning of a new way of thinking about the evolutionary process.
Rather, we can find multiple arguments that provide strong support for the ideas proposed here in the study published by Bush et al. more than 30 years ago [ 102].
While I will be working on mathematizing the ideas proposed here and invite others to do the same, my goal in this paper is different it is to propose, for the first time, the conceptual foundation that will make such quantitative analysis possible as well as elicit empirical work directly.
With regard to the ideas proposed here, it will be particularly interesting to see if characters can be identified that have contributed to the progressive adaptation of the species along the barriers, and when those are due to recessive characters, whether this is accompanied by more significant reproductive isolation from the ancestral stock.
Two new ideas are proposed here.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com