The idea of alteration has great potential in the future of architectural thinking and already begins to reconfigure and assert new conceptions and definitions of the architectural object or more specifically, qualities of architectural object-hood.
Faussillon et al. reported overexpression of another cyclin, cyclin D2 (CCND2), in 86% of Wilms' tumor, supporting the idea that alteration at the G1/S cell cycle control point is of biological significance in nephroblastoma [25].
Many oncogenes and tumour suppressor genes have been thoroughly investigated and they provide credence to the idea that alteration of their normal physiological actions and regulations can have an adverse impact on gene expression, resulting in various diseases including cancer.
Initiated by the idea that alterations in the composition of the intestinal microbiota are associated with intestinal inflammation in inflammatory bowel disease, several studies investigated whether faecal microbiota transplantation would be an equally suitable approach for these devastating disorders.
The idea that alterations at the global level of gene expression regulation might be important in mediating the risk for autism or other disease states has been largely underexplored.
While our analyses excluded the idea that alterations in growth hormone and basal glucose levels led to this phenotype in Rip-Cre;Vhl f/f mice, it is described in the literature that pVHL regulates glucose metabolism in liver and kidney cells [10], [36].
These studies support the idea that alterations at different hierarchical levels in bone are induced by in vivo mechanical stimulation.
Experimental evidence obtained in recent years supports the idea that alterations in the neuroendocrine system may contribute significantly to the tumorigenic process.
In agreement with the idea that alterations in the gastrointestinal microbiota are involved in IBS, there has been considerable success with treatments that reverse this.
Collectively, these findings strongly support the idea that alterations in DNA methylation have a substantial impact on fibroblast phenotype and promote the differentiation to pathological, scar-forming myofibroblasts.
These results are consistent with the idea that alterations to membrane function and integrity is a short-term response (impacted by the in-rush of water) and that the recovery of photosynthesis is a long-term response.
