The aim of this study was to compare the pathophysiological differences in motor nerve membrane polarization and voltage-gated sodium channel function between CIP patients and critically ill patients not developing CIP during their ICU stay (ICU controls).
Serum and plasma samples were collected from septic shock patients and ICU controls (ICU patients with the systemic inflammatory response syndrome but not suspected of having an infection).
Third, we endeavored to match the final cohort of AML cases with non-AML ICU controls by a ratio of 1 5; however, we recognize these ICU controls still represent a heterogeneous population and, despite similar illness severity, have observed differences that may impact outcome (i.e. primary diagnosis, prevalence of co-morbid illness).
ICU patients underwent electrophysiological nerve conduction studies and were categorized as either ICU controls or CIP patients.
In cohort I, histone H4 levels were significantly elevated compared to ICU controls (sepsis cohort I: median 0.35, IQR 0.2 to 0.46) versus ICU controls: median 0.06 (0.05 to 0.07) ng/ml, P <0.05; Figure 1A).
Each case was matched by age, sex, and illness severity (ICU only) to two control groups: hospitalized AML controls, and non-AML ICU controls.
In brief, the replication sample consisted of n = 44 subjects ("ICU controls") who did not develop AKI during a 7-day observation period after hospital ICU admission, as well as n = 11 subjects (ICU cases) who did develop AKI, as defined above.
In ICU survivors, subjects with CKD prior to admission had significantly elevated risk of developing ESRD in comparison to ICU controls.
Laboratory data p value compares ICU controls with CIP patients.
MEMFIT data showing best fit of current changes in % for ICU controls.
p value compares ICU controls versus CIP patients (Mann-Whitney U).
