While this could be temporarily useful in decreasing elevated ICP, it must be underlined that prolonged aggressive hyperventilation (PaCO2 < 25 30 mmHg) is deleterious for patients with TBI by decreasing CBF below the ischemic threshold [48, 49].
Even though these observations support the importance of N34S mutations in ICP, it still remains to be determined whether N34S mutations are causative.
Although no statistical evaluation was performed to correlate serum sodium with ICP, it appears that ICP decreased as serum sodium increased.
While this could be temporarily useful in decreasing elevated ICP, it must be underlined that prolonged aggressive hyperventilation (PaCO2 < 25 30 mmHg) is deleterious for patients with TBI by decreasing CBF below the ischemic threshold [ 48, 49].
Free water given in the form of 0.45% saline or 5% dextrose in water can exacerbate cerebral edema and increase ICP because it flows down its osmotic gradient into injured brain tissue (Class III, Level of Evidence C) [ 50].
This provides rich in-depth qualitative data about the ICP, whether it is working for patients and family of patients and if it contributes to a good death.
It is not known why sulfated progesterone metabolite levels are found at supraphysiological concentrations in ICP, but it has been suggested that excretion of sulfated progesterone metabolites may be impaired due to aberrant hepatobiliary excretion and or dysregulated phase II metabolism of progesterone.
To perform the cloud-based ICP registration, it is important to find overlaps of the same objects in two clouds.
Upon examination of the few samples with totals falling below this range (via SEM and LA-ICP-MS), it is most likely that lower totals are reflective of the presence of additional, un-analysed elements.
Before providing a few selected examples of the kinds of information contained in a concretion that can be revealed using LA-ICP-MS, it is pertinent to assess the capabilities and limitations inherent in the developed method.
