Exact(5)
Although no statistical evaluation was performed to correlate serum sodium with ICP, it appears that ICP decreased as serum sodium increased.
While this could be temporarily useful in decreasing elevated ICP, it must be underlined that prolonged aggressive hyperventilation (PaCO2 < 25 30 mmHg) is deleterious for patients with TBI by decreasing CBF below the ischemic threshold [48, 49].
Even though these observations support the importance of N34S mutations in ICP, it still remains to be determined whether N34S mutations are causative.
While this could be temporarily useful in decreasing elevated ICP, it must be underlined that prolonged aggressive hyperventilation (PaCO2 < 25 30 mmHg) is deleterious for patients with TBI by decreasing CBF below the ischemic threshold [ 48, 49].
Aside from altering the vascular component of ICP, it is also possible (and as yet unknown) that the CSF or parenchymal compartments are altered – for example, by altering CSF production or reabsorption, or by affecting the osmotic composition of the parenchymal interstitium.
Similar(55)
Free water given in the form of 0.45% saline or 5% dextrose in water can exacerbate cerebral edema and increase ICP because it flows down its osmotic gradient into injured brain tissue (Class III, Level of Evidence C) [ 50].
Interestingly, fundus changes (oedema of the optic disk) started several days after the beginning of raised ICP, making it not clinically pertinent for early detection of raised ICP.
This provides rich in-depth qualitative data about the ICP, whether it is working for patients and family of patients and if it contributes to a good death.
It is not known why sulfated progesterone metabolite levels are found at supraphysiological concentrations in ICP, but it has been suggested that excretion of sulfated progesterone metabolites may be impaired due to aberrant hepatobiliary excretion and or dysregulated phase II metabolism of progesterone.
To perform the cloud-based ICP registration, it is important to find overlaps of the same objects in two clouds.
From X-ray diffraction and ICP measurements, it was found that the pristine LiNi0.5Mn0.5O2 had a single phase of the layered rock-salt structure although the Ni content was slightly rich compared with the nominal one.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com