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While the accuracy, performance and reproducibility of paper-based ICP device were lower than conventional ICP device, it was always suffered from the extraction of preconcentrated sample and the instability.
b Two step preconcentration method in paper-based ICP device.
Fig. 2 The I V responses of paper-based ICP device a with nanoporous membrane and b without nanoporous membrane.
In this work, we have demonstrated an economic and fast-fabricable ICP device on a commercial paper for selective preconcentration.
Fig. 4 Preconcentration and separation of muc1 and lamp-2 gene fragments in the paper-based ICP device under 50 V.
The paper-based ICP device was fabricated by cellulose paper (Whatman grade 1, Sigma-Aldrich Co). with slide glass and E-tube caps (Fig. 1).
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Such paper-based ICP devices would be a promising tool due to an economic fabrication, the easy extraction of concentrated sample and an easy disposability.
The I V responses in the paper-based ICP devices with or without nanoporous membrane were plotted in Fig. 2a, b, respectively.
Further, ICP devices are invasive and insertion requires expertise [ 1, 2].
Most times the ICP measurement device was removed at surgery.
The majority of the patients (n = 504; 65.7 %) were managed conservatively and had either no surgical procedure or insertion of an ICP monitoring device only.
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