Sentence examples for ich model from inspiring English sources
In the ICH model, treatments were administered 1 h after collagenase injection.
In the present study, the authors investigated the neuroprotective effect of ASCs in an intracerebral hemorrhage (ICH) model.
In summary, ASCs transplantation in the ICH model reduced both acute cerebral inflammation and chronic brain degeneration, and promoted long-term functional recovery.
Here we show that VPA induces neuroprotection in a murine ICH model and that its neuroprotective effects are mediated by transcriptional activation following HDAC inhibition.
We test this duplex ELISA on our porcine intracerebral hemorrhage (ICH) model and show that it is as accurate and sensitive as independent single ELISAs.
Since most ICH research has used male models, this study was designed to provide an overall view of ICH-induced iron deposits at different time points (1 to 28 days) in aged (18-month old) female Fischer 344 rat ICH model and to investigate the neuroprotective effects of minocycline in those rats.
Additionally, because the current, commonly used blood- and collagenase-induced ICH models cannot fully and adequately mirror human ICH events, we applied multiple models in our study to reduce possible translational pitfalls.
As indicated by both clinical and preclinical studies, reduction of hematoma volume and decreased tissue injury improves outcomes in ICH models [ 50].
Intracerebral injection of bacterial collagenase (a form of MMP) causes hemorrhage [ 123] and a number of MMPs are upregulated in animal ICH models (e.g. MMP-2, −3, −9 and −12 [ 124]).
Although we provide proof of concept and elucidate the mechanisms of action of EC in our ICH models, additional efforts should be made before clinical trials can be considered in the future.
In a previous study, we have shown that human neural stem cells (hNSCs) transplanted in brain of mouse intracerebral hemorrhage (ICH) stroke model selectively migrate to the ICH lesion and induce behavioral recovery.
