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The assumption that flow diverters should be considered as an alternative (not a first choice treatment) mainly for IAs excluded from the treatment by other methods, especially by clipping or coiling may be correct.
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A large retrospective cohort study investigating risk factors and outcome of ICU patients with IA (excluding those with classic risk factors) showed that a 1-day delay in starting effective antifungal therapy was associated with a longer length of stay (by 1.28 days) and 4% higher total costs per day (P < 0.001).
FIGO stages IA were excluded from predictive modelling, as only one event was observed in this group.
The families had no DNA mismatch repair defects in tumor tissue or in the germline ; furthermore, germline mutations in bone morphogenetic protein receptor type IA were excluded.
Of 188 IA-positive children in DAISY, 19 were excluded from analyses of IA because they tested autoantibody positive on their first study visit (i.e., left-censored).
For this study, we further excluded one participant missing iAs measurements and participants with iAs (n = 210), MMA (n = 29) or DMA (n = 1) below the limit of detection.
The second criterion was based on IA-related consultations and prescriptions, defined as 'at least four contacts or one episode with a diagnostic code for IA (L88), combined with at least two prescriptions with the IA diagnostic code (excluding DMARDs/biological agents)'.
Individuals with glutamic acid decarboxylase and/or protein tyrosine phosphatase IA-2 antibodies positive were excluded and mitochondria tRNA Leu UUR) nt3243 A-to-G mutation carriers were excluded as well.
To ensure that only newly diagnosed IA patients were included, we excluded patients with an L88-code within 365 days from start of registration.
To focus on iAs and its methylation products, we excluded the 275 participants who reported eating seafood in the 2 days before sample collection.
We decided to exclude IA from our definition of autoantibody negativity, because we did not measure autoantibodies at onset.
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