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We report here that Rpr not only inhibits IAP function, but also greatly decreases IAP abundance.
Expressed by most eukaryotic organisms (reviewed in [ 423]), their IAP function is presumably conserved in corals.
Thus, IAP function is central to the modulation of the apoptotic cascade.
We then microinjected oocytes with a sub-threshold dose of cytochrome c and Smac, a protein that functions as an inhibitor of IAP function 21.
It is widely accepted that the inhibitor of apoptosis proteins (IAP) function as a key negative regulator in TRAIL resistance [ 11, 12].
In vitro, peptides containing N-terminal residues of mature Smac/DIABLO have been shown to promote apoptosis by blocking IAP function.
Similar(52)
IAPs function to block cell death by binding to and inhibiting the action of caspases involved in the execution phase of apoptosis (Holcik and Korneluk, 2001; Holcik et al, 2001).
The inhibitor of apoptosis protein (IAP) family function to block apoptosis by caspase-dependent and caspase-independent means [ 45].
Effects on extravascular lung water index (EVLWI), intra-abdominal pressure (IAP), organ function, and vasopressor therapy were recorded during 1 week.
We have observed that the presence of Smac hastens the induction of apoptosis in oocytes aged on the bench (data not shown), further supporting the hypothesis that IAP levels function as a brake to apoptosis in the oocyte.
The aim of the present study was to investigate whether the evolution of IAP, liver function assessed by the plasma disappearance rate of indocyanine green (PDRICG) [ 5] and extra-vascular lung water is related to the type of support during PP.
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