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The solution conformation of a fully sulfated heparin-derived tetrasaccharide, I, was studied in the presence of a 4-fold excess of Ca2+.
ΔU-tetrasaccharide I was studied previously using NOESY spectroscopy and the authors (Mikhailov et al. 1996) have reported the interglycosidic dihedral angles of their final structure.
First, formation of the experimentally observed sulfenylated allylic alcohol intermediate 5 by gold-catalyzed regioselective addition of thiophenol 2 a to the triple bond of propargylic alcohol 1 i was studied.
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