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The debate about the presence of bacteria in MCs type I is ongoing as Wedderkopp et al. [ 19] found no trace of anaerobic bacteria in 24 biopsies taken from vertebrae affected by MCs type I.
Fortuitously, the phase I study was ongoing at that time with PF-02341066.
I believed that that was ongoing and that he would bring back to me a consensus recommendation.
7 A live-attenuated oral vaccine candidate (Centre for Vaccine Development CVDD) 1901, University of Maryland) has also been shown to be well tolerated and immunogenic in phase I trials and further phase I studies are ongoing.
Phase I studies are ongoing (Dupont et al, 2003).
MEDI4376 targets PD-L1, and phase I trial is ongoing.
Maraviroc is in the late stages of clinical development, and phase IIb/III trials are ongoing (Table 5).
Trials of sapacitabine in combination with established agents, such as decitabine, have been initiated [27] and phase I/II trials are ongoing [8].
The addition of oxaliplatin or irinotecan to capecitabine could further improve chemoradiation efficacy outcomes in the future, and phase I trials are ongoing.
Several Phase I studies are ongoing in which newly developed anti-CXCR4 antagonists (POL6326, BKT140, TG0054, NOX-A12) are challenged in hematological neoplasias as mobilizing agents, but there are no ongoing clinical trials in solid tumors.
The dosage of cytostatics was reduced if WHO-toxicity III° or haematotoxicity III/IV° appeared in between of two treatment courses or toxicity >WHO I° was ongoing on the first day of the following cycle (except for leukocytopenia: >WHO II° and thrombocytopenia: >II°).
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