Sentence examples for i trials it from inspiring English sources

133 In addition, during other Phase I trials, it was found that arzoxifene caused decreases in proliferating cell nuclear antigen, IGF-1, and IGF binding protein 3. 142 Though no objective response was seen, the hormonal data and results on endometrium prompted Phase II trials.

In a phase-III trial it was recently shown that an adjuvant renal cell carcinoma (RCC) vaccine (Reniale) reduces the risk of tumour progression following nephrectomy.

So far I think in the phase I trial it's not been a major problem.

In a preliminary reported phase I trial, it was shown that cetuximab can be safely administered at 500 mg m−2 every 2 weeks, with similar pharmacokinetic and pharmacodynamic behaviour compared with the weekly schedule (Tabernero et al, 2006).

In a phase I trial, it was reported to be tolerated as an infusion at a dose of 0.8 mg/kg on days 1, 8, and 15 in a 28-day cycle [44].

However, without conducting a randomised phase II/III trial, it is unclear whether this treatment regimen would be more effective than second-line or third-line standard therapy.

PTK787 demonstrated efficacy in preclinical and Phase I/II trials where it significantly reduced tumor vessel density and in some cases induced tumor regression [12].

Galiximab is a chimeric anti-CD80 mAb initially evaluated in psoriasis in phase I/II trials, where it was found to have minimal side effects.

In most phase I oncology trials, it is often stated that the dose increments follow a "modified-Fibonacci sequence".

However, prior to embarking on large phase II/III clinical trials it is critical to develop new strategies for determining the mechanism of action of ULD IL-2 in participants with T1D.

4. In screening for toxic effects of microbicides in Phase I safety trials, it may be important to monitor a broad range of inflammatory cytokines vs time, and exfoliation of columnar epithelium.