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The Phase I trials, begun in 2007, tested for safety.
Phase I trials generally focus on safety using healthy volunteers.
We reviewed published data on the safety and efficacy of Phase I trials in older patients.
As a consequence, clinical phase I trials document a wide range of side effects.
Few clinical studies include older patients, however, and particularly few Phase I trials.
GSK126, a specific inhibitor of EZH2, is undergoing phase I trials for hypermethylation-related cancers.
Although both compounds passed phase I trials, they failed in their respective phase II trials.
For radiotherapy and chemoradiotherapy phase I trials, the primary endpoint must reflect both effectiveness and potential treatment toxicities.
Data from phase I trials show that bortezomib induces predictable, dose-related, reversible inhibition of proteasome activity.
Your odds of benefiting are extremely low because Phase I trials typically start with tiny doses.
Probands receiving the agent within phase I trials reported on an alteration of visual perception.
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