Exact(5)
In a phase-III trial it was recently shown that an adjuvant renal cell carcinoma (RCC) vaccine (Reniale) reduces the risk of tumour progression following nephrectomy.
So far I think in the phase I trial it's not been a major problem.
In a preliminary reported phase I trial, it was shown that cetuximab can be safely administered at 500 mg m−2 every 2 weeks, with similar pharmacokinetic and pharmacodynamic behaviour compared with the weekly schedule (Tabernero et al, 2006).
In a phase I trial, it was reported to be tolerated as an infusion at a dose of 0.8 mg/kg on days 1, 8, and 15 in a 28-day cycle [44].
However, without conducting a randomised phase II/III trial, it is unclear whether this treatment regimen would be more effective than second-line or third-line standard therapy.
Similar(52)
133 In addition, during other Phase I trials, it was found that arzoxifene caused decreases in proliferating cell nuclear antigen, IGF-1, and IGF binding protein 3. 142 Though no objective response was seen, the hormonal data and results on endometrium prompted Phase II trials.
fix8 is a little application with a wow factor to it, I'd even go as far as calling it pretty cool, even if I couldn't get my webcam to play with Vista so I could trial it.
Moreover, in a phase I clinical trial it was found that this combined protocol composition is well tolerated by the patients.
73 In a Phase I clinical trial, it was found to be safe and well tolerated in healthy women, with no evidence of systemic toxicity or absorption.
PTK787 demonstrated efficacy in preclinical and Phase I/II trials where it significantly reduced tumor vessel density and in some cases induced tumor regression [12].
Galiximab is a chimeric anti-CD80 mAb initially evaluated in psoriasis in phase I/II trials, where it was found to have minimal side effects.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com