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RNA polymerase I synthesizes ribosomal RNA (rRNA), and RNA polymerase III synthesizes transfer RNA (tRNA) and other small RNAs.
RNA polymerase I synthesizes three of the four types of rRNA (called 18S, 28S, and 5.8S RNA); therefore it is active in the nucleolus, where the genes encoding these rRNA molecules reside.
RNA polymerase I synthesizes a large ribosomal RNA precursor (pre-rRNA) that includes three out of the four ribosomal RNAs constituting the ribosomal subunit, i.e. the 18S, 5.8S and 25S rRNAs in yeast.
RNA polymerase I synthesizes the ribosomal RNAs and this activity is cell cycle regulated.
The enzyme ST6Gal I, synthesizes the Siaα(2,6 Galβ(1,4)GlcNAc sequence, known as CDw75 antigen, a surface molecule in B lymphocytes.
Eukaryote nuclei generally encode three RNA polymerases: RNA polymerase I synthesizes a pre-rRNA, 45S, which matures into 28S, 18S and 5.8S rRNAs that will form the major RNA sections of the ribosome.
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