One can then infer whether each SNP i is skewed in each individual dataset d based on the posterior probability Pr (b id, c id | X i, N i, Π, V, W ) = ∑ a i Pr (a i, b id, c id | X i, N i, Π, V, W ) after summing over all possible values of a i (see Additional file 1: Supplemental Method S.4 equation S.14).
In order to solidify this initial result, we need to look in detail at several issues, which can potentially affect our analysis (see also Additional file 1: Supplemental Text S1): (i) Gene to reaction mapping.
For detailed information on experimental conditions and calculation of [Ca2+] i, see Supplemental Material (doi 10.1289/ehp.0901339).
Further experiments showed that NG2+ pericytes were tightly associated with airway capillaries under baseline conditions (Fig. 5, I– L, Supplemental Video S3).
The database for systemic population lampalizumab PK analysis contained data from a total of 117 patients with GA in both phase Ia and Ib/II studies (Supplemental Table 1).
For a broad view of the EDSP chemicals in the context of the entire ToxCast phase I set, Supplemental Material, Figure 1 (doi:10.1289/ehp.1002180) shows the ToxPi profiles for all chemicals, with the initial EDSP Tier 1 chemicals highlighted by red frames.
To assess the importance of KIR HLA class I KIR interaction, NKG2A−KIR+ NK cells were classified into three subsets based on the target HLA-class I genotype (supplemental table S1): a subset exclusively expressing matched KIRs, a subset expressing only mismatched KIRs, and a subset co-expressing matched and mismatched KIRs.
To assess pluripotency of the expanded hESCs, we analyzed cell surface expression of the markers SSEA4 and Tra-1 60, Tra-1 60as the pan-human marker Tra-1–85, an indicator of the proportion of hESCs present (Fig. 6B(i) and Supplemental Fig. S2).
After rare haplotypes were collapsed into a single category, remaining haplotypes containing the deleterious SNPs in AGTR1 and ALOX15 had low probability-weighted haplotype frequencies [3% for AGTR1-E and AGTR1-F, 9% for ALOX15-C, and 3% for ALOX15-I; see Supplemental Material, Table 1 (doi:10.1289/ehp.0901535)].
The force curves were corrected for the bending of the cantilever (36) to calculate the tip-sample separation and to build force vs. indentation (F-I) curves (Supplemental Fig. S1).
