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To directly impute summary statistics while (i) substantially reducing the computational burden and (ii) retaining imputation accuracy, we propose Direct Imputation of summary STatistics (DIST).
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In particular, site specific PEGylation of A1-III alginate lyase (i) substantially reduced binding of naïve human antibody repertoires (Fig. 5a), and (ii) blocked >50% of specific, human, anti-A1-III scFv antibody fragments (Fig. 5b).
The methods were shown to (i) substantially reduce the computational burden and (ii) be practically as accurate as commonly used genotype imputation methods.
As for added savings, he quipped: "I would substantially reduce police overtime by cutting Howard Safir's detail," referring to the former police commissioner.
However, commercially available NF membranes have a high rejection for divalent salts (i.e., Na2SO4), substantially reducing the salt recovery and membrane flux when treating textile wastewater containing Na2SO4.
I have initiated several clinical trials using monoclonal or polyclonal antibodies to achieve transient lymphocyte depletion, substantially reducing the need for immunosuppression in humans.
These bubbles then burst, substantially reducing demand.
We are substantially reducing the population at Guantánamo Bay without adding to it.
But they don't deliver on their goal of substantially reducing the number of abortions.
Recognizing the powerful interdependence is paramount to substantially reducing U.S. cyber risk.
These health improvements given by universal breastfeeding would translate to substantially reducing health care costs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com