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Our results suggest a dual role for dasatinib in both (i) stimulating osteoblast differentiation leading to a direct increase in bone formation, and (ii) downregulating RANKL synthesis by osteoblasts leading to an indirect inhibition of osteoclastogenesis.
This is possibly by: i) stimulating glycogenolysis and accumulating glucose-6-phosphate [ 68, 71, 72] (a strong inhibitor of the hexokinase enzyme) [ 73, 74]; or ii) by reducing glucose transport across the membrane [ 75- 77].
These conclusions are based on (i) stimulating the signaling pathway either by soluble TRAIL or by transfection of LMP1-TRAIL receptor fusion proteins, (ii) the use of either small interfering RNA (siRNA -mediated knockdown or expresiRNA -mediated cell lines and (iii) rescue experiments also using different mutants of FADD and caspase-8.
Experimental application of JH to workers of different social insects has been shown to induce two major types of changes; such as (i) stimulating young workers to carry out functions that are usually performed by older individuals [ 3] or (ii) inducing workers to go through physical changes and differentiate from one phenotype to another [ 4].
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The slaughter of young men and the devastation of World War I stimulated the government to draw more widely from the reservoirs of foreign manpower.
Developments in aviation during World War I stimulated interest in cloud formations and in their importance as an aid in short-range weather forecasting.
I would be vain to say that I stimulated the rise of Islamic radicalism, but I was the pretext that they found, given that they were looking for pretexts".
As shown in Figure 3, the IDG-I fraction and SUL-III stimulated mitogenic responses of murine splenocytes, in the dose range of 0.31 to 1.25 μg/ml, respectively.
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The anaphylatoxin C3a is generated following bacterial infection and from IgE/FcεRI stimulated human mast cells [1].
(I ) Stimulated Nfil3 −/− liver trNK cells produce cytokines similar to WT liver trNK cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com