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Indeed, it has already been successfully applied to interrogate global gene expression patterns in stage I serous invasive versus borderline ovarian tumors [37].
The rules seem to work less well for abscesses, fibromas, and stage I serous borderline tumours.
Afify et al (2006) reported that the expression of CD44s and CD44v5 is more common in stage III than in stage I serous ovarian carcinomas and suggested a role for CD44 and stromal HA in the dissemination of EOC.
Moreover, specific subtypes of breast, ovarian, and lung cancers exhibit distinct patterns of alterations; the basal-like subtype of breast cancers (typically estrogen receptor-negative) have greater CIN than luminal subtypes, while type II high-grade serous ovarian carcinomas have greater CIN than type I serous ovarian cancers [ 87, 88].
Reduced expression took place in Stage II -III serous ovarian cancer by Ozaki et al [ 69] but not in borderline serous ovarian cystadenoma or other histology types of ovarian cancer.
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In 33 stage I cancers, serous adenocarcinomas represent six cases, mucinous adenocarcinomas 12 cases, endometrioid adenocarcinomas six cases, and clear cell carcinomas nine cases.
These findings demonstrate a strong correlation between the p53 IHC score and presence of TP53 gene mutation and suggest that in both type I and serous endometrial carcinomas that TP53 gene mutations that inhibit p53 protein function provide a selective advantage to tumour cells, resulting in their enrichment in the tumour population and generation of a highly aggressive tumour.
We constructed two human endometrial carcinoma tissue microarrays (TMA; see Supporting Information Table 1), in total comprising tumour punches from 463 endometrioid AdCas (type I), 34 serous AdCas (type II), 19 clear cell AdCas (type II), 16 undifferentiated carcinomas (type II) and 16 carcinosarcomas.
Prognostic determinants in patients with stage I uterine papillary serous carcinoma: a 15-year multi-institutional review.
METHODS: Using genome-wide expression analysis, we compared a series of 31 advanced stage (III or IV) serous ovarian cancers from patients who survived either less than 2 years or more than 7 years with three normal ovarian epithelial samples.
Stage I: 10E (papillary serous cystadenoma), 10K (mucinous cystadenocarcinoma).
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