"Is central sensitization something we want to label as a pathological process or is this something we are all capable of doing if we prepare ourselves intellectually?" he said.
However, CK2-I-mediated sensitization of p53 null cells to TNF α could have resulted from downregulation of NF- κB activity.
Activity-dependent changes in spinal function encompass long-term potentiation (LTP) of individual synapses as well as an increase in neuronal and non-neuronal excitation in the spinal dorsal horn, leading to increased pain sensitivity, i.e. central sensitization (Ji et al., 2003; Sandkühler, 2009).
For control purposes, groups were included which received only prophylactic immunization, but no sensitization (i.e. group P+/S−), neither prophylactic immunization nor sensitization (i.e. group PBS) or only sensitization (i.e. group P−/S+).
In all type I allergic reactions, sensitization occurs when a substance triggers the immune system to recognize it as a threat to the body.
This disrupted random grain boundary network and large fraction of low CSL boundaries reduced the propensity to sensitization, i.e. carbide precipitation and Cr depletion.
Weekly dosing produced tolerance to nicotine's decreasing effects on vertical activity and increases (i.e., sensitization) in horizontal activity at all doses, and these effects persisted for at least 3 weeks.
The present study was designed to explore in rats whether repeated exposure to ethanol during infancy modifies subjects' sensitivity to the stimulating effect of the drug, either increasing or decreasing its magnitude (i.e. sensitization or tolerance, respectively).
The linear increase, i.e., sensitization of pain scores, was not different between phases.
It is well established that activation of NMDARs plays an essential role in spinal cord synaptic plasticity (i.e., central sensitization) and pain hypersensitivity after tissue injury.
